Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceSCGHPEVGRLGGGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQGL
    • Amino acids1009 to 1058

Associated products

Specifications

Our Abpromise guarantee covers the use of ab86150 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Gli1 antibody (ab49314)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

General Info

  • Alternative names
    • GLI
    • Gli 1
    • GLI family zinc finger 1
    • GLI Kruppel family member 1
    • gli1
    • GLI1_HUMAN
    • Glioma associated oncogene 1
    • Glioma associated oncogene homolog
    • Glioma associated oncogene homolog 1 (zinc finger protein)
    • Glioma-associated oncogene
    • Oncogene GLI
    • Zfp 5
    • Zfp5
    • Zinc finger protein GLI 1
    • Zinc finger protein GLI1
    see all
  • FunctionActs as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.
  • Tissue specificityTestis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract.
  • Sequence similaritiesBelongs to the GLI C2H2-type zinc-finger protein family.
    Contains 5 C2H2-type zinc fingers.
  • Post-translational
    modifications
    Phosphorylated in vitro by ULK3.
  • Cellular localizationCytoplasm. Nucleus. Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization. Translocation to the nucleus is promoted by interaction with ZIC1.
  • Information by UniProt

References for Human Gli1 peptide (ab86150)

ab86150 has not yet been referenced specifically in any publications.

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