Human Glutamate Receptor 1 (AMPA subtype) peptide (ab28424)

Overview

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab28424 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Glutamate Receptor 1 (AMPA subtype) antibody (ab31232)

  • FormLiquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • GLUR 1
    • GLUR A
    • AMPA 1
    • AMPA selective glutamate receptor 1
    • AMPA-selective glutamate receptor 1
    • GluA1
    • GLUH1
    • GluR K1
    • GluR-1
    • GluR-A
    • GluR-K1
    • GLUR1
    • GLURA
    • GluRK1
    • Glutamate receptor 1
    • Glutamate receptor ionotropic
    • Glutamate receptor ionotropic AMPA 1
    • Glutamate receptor, ionotropic, AMPA 1
    • Gria1
    • GRIA1_HUMAN
    • HBGR1
    • MGC133252
    • OTTHUMP00000160643
    • OTTHUMP00000165781
    • OTTHUMP00000224241
    • OTTHUMP00000224242
    • OTTHUMP00000224243
    see all
  • FunctionIonotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
  • Tissue specificityWidely expressed in brain.
  • Sequence similaritiesBelongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.
  • Post-translational
    modifications
    Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis.
  • Cellular localizationCell membrane. Endoplasmic reticulum membrane. Cell junction > synapse > postsynaptic cell membrane. Interaction with CACNG2 promotes cell surface expression.
  • Information by UniProt

References for Human Glutamate Receptor 1 (AMPA subtype) peptide (ab28424)

This product has been referenced in:
  • Naskar S  et al. pT305-CaMKII stabilizes a learning-induced increase in AMPA receptors for ongoing memory consolidation after classical conditioning. Nat Commun 5:3967 (2014). Read more (PubMed: 24875483) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"