Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-RDAYREAQQLVQR
    • Amino acids
      648 to 660

Associated products

Specifications

Our Abpromise guarantee covers the use of ab48046 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-GRK2 antibody (ab47999)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • ADRBK1
    • Adrenergic beta receptor kinase 1
    • ARBK1_HUMAN
    • BARK
    • BARK1
    • Beta adrenergic receptor kinase 1
    • Beta ARK 1
    • Beta ARK1
    • Beta-adrenergic receptor kinase 1
    • Beta-ARK-1
    • FLJ16718
    • G protein coupled receptor kinase 2
    • G-protein coupled receptor kinase 2
    • GRK2
    see all
  • Function
    Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
  • Tissue specificity
    Expressed in peripheral blood leukocytes.
  • Sequence similarities
    Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 PH domain.
    Contains 1 protein kinase domain.
    Contains 1 RGS domain.
  • Information by UniProt

References

ab48046 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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