Overview

  • Product name
    Human HDPTP peptide

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab12580 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    This peptide has been shown to block the detection of a 179kDa band by anti-HDPTP (ab12553) in Western Blot.
  • Applications

    Blocking - Blocking peptide for Anti-HDPTP antibody (ab12553)

  • Form
    Liquid
  • Additional notes
    This peptide has been shown to block the detection of a 179kDa band by anti-HDPTP (ab12553) in Western Blot.

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • DKFZP564F0923
    • EC 3.1.3.48
    • HD PTP
    • HD-PTP
    • His domain containing protein tyrosine phosphatase
    • His domain protein tyrosine phosphatase
    • His domain-containing protein tyrosine phosphatase
    • KIAA1471
    • Protein tyrosine phosphatase non receptor type 23
    • Protein tyrosine phosphatase TD 14
    • Protein tyrosine phosphatase TD14
    • PTN23_HUMAN
    • PTP TD14
    • PTP-TD14
    • PTPN 23
    • PTPN23
    • Tyrosine protein phosphatase non receptor type 23
    • Tyrosine-protein phosphatase non-receptor type 23
    see all
  • Function
    May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.
  • Sequence similarities
    Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
    Contains 1 BRO1 domain.
    Contains 2 TPR repeats.
    Contains 1 tyrosine-protein phosphatase domain.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm > cytoskeleton > cilium basal body.
  • Information by UniProt

References

ab12580 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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