Overview

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab35706 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General info

  • Alternative names
    • from Entrez Gene ;
    • HEC
    • HEC
    • HEC 1
    • Highly Expressed in Cancer
    • Highly Expressed in Cancer
    • Highly expressed in cancer protein
    • Highly expressed in cancer rich in leucine heptad repeats
    • HsHec1
    • hsNDC80
    • Kinetochore Associated 2
    • Kinetochore Associated 2
    • Kinetochore associated protein 2
    • Kinetochore protein Hec1
    • Kinetochore protein NDC80 homolog
    • Kinetochore-associated protein 2
    • KNTC 2
    • KNTC2
    • KNTC2
    • NDC 80
    • NDC80
    • NDC80 homolog kinetochore complex component
    • NDC80 kinetochore complex component homolog
    • NDC80, S. cerevisiae, homolog of
    • NDC80_HUMAN
    • Retinoblastoma associated protein HEC
    • Retinoblastoma-associated protein HEC
    • TID3
    see all
  • FunctionActs as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.
  • Sequence similaritiesBelongs to the NDC80/HEC1 family.
  • Developmental stageExpression peaks in mitosis.
  • Post-translational
    modifications
    Phosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. May also be phosphorylated by AURKA and AURKB.
  • Cellular localizationNucleus. Chromosome > centromere > kinetochore. Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.
  • Information by UniProt

References for Human HEC1 peptide (ab35706)

ab35706 has not yet been referenced specifically in any publications.

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