Overview

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab12306 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General info

  • Alternative names
    • DKFZp762F1811
    • Factor inhibiting HIF 1
    • Factor inhibiting HIF-1
    • Factor inhibiting HIF1
    • FIH 1
    • FIH-1
    • FIH1
    • FLJ20615
    • FLJ22027
    • HIF1AN
    • HIF1N_HUMAN
    • Hypoxia inducible factor 1 alpha inhibitor
    • Hypoxia inducible factor 1 alpha subunit inhibitor
    • Hypoxia inducible factor asparagine hydroxylase
    • Hypoxia-inducible factor 1-alpha inhibitor
    • Hypoxia-inducible factor asparagine hydroxylase
    • Peptide aspartate beta dioxygenase
    • prolyl hydroxylase
    see all
  • FunctionHydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases.
  • Sequence similaritiesContains 1 JmjC domain.
  • Cellular localizationNucleus.
  • Target information above from: UniProt accession Q9NWT6 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

References for Human HIF1AN peptide (ab12306)

ab12306 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"