Your journey to publication continues here Discover why

Human Histone H2A (unmodified ) peptide (ab13202)



  • NatureSynthetic


Our Abpromise guarantee covers the use of ab13202 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • FormLiquid
  • Additional notesNon-modified control peptide for ab12950
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Information available upon request.

General Info

  • Alternative names
    • H2A
    • H2a 615
    • H2A GL101
    • H2A histone family member A
    • H2A.1
    • H2A.2
    • H2A/a
    • H2A/m
    • H2A/O
    • H2A/q
    • H2A1B_HUMAN
    • H2AFA
    • H2AFE
    • H2AFL
    • H2AFM
    • H2AFO
    • H2AFQ
    • HIST1H2AE
    • HIST1H2AJ
    • HIST2H2AA
    • HIST2H2AA3
    • HIST2H2AB
    • HIST2H2AC
    • Histone 1 H2ae
    • Histone 2 H2aa3
    • Histone 2 H2ab
    • Histone 2 H2ac
    • Histone H2A type 1 B
    • Histone H2A type 1 C
    • Histone H2A type 1 E
    • Histone H2A type 1 J
    • Histone H2A type 1-B/E
    • Histone H2A.2
    • Histone H2A/a
    • Histone H2A/m
    • MGC74460
    see all
  • FunctionCore component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
  • Sequence similaritiesBelongs to the histone H2A family.
  • Post-translational
    The chromatin-associated form is phosphorylated on Thr-121 during mitosis.
    Deiminated on Arg-4 in granulocytes upon calcium entry.
    Monoubiquitination of Lys-120 by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3. Monoubiquitination of Lys-120 by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Monoubiquitination and ionizing radiation-induced 'Lys-63'-linked ubiquitination are distinct events.
    Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1.
    Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Cellular localizationNucleus. Chromosome.
  • Information by UniProt

Human Histone H2A (unmodified ) peptide images

  • ELISA eluate (red, blue) and flow through (green) using immunizing peptide (ab12952). Eluate (orange) and flow through (grey) using un-modified peptide (ab13202).

    This demonstrates that ab12950 specifically recognises mono-methyl K127 compared to the unmodified peptide.

References for Human Histone H2A (unmodified ) peptide (ab13202)

ab13202 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab13202.
Please use the links above to contact us or submit feedback about this product.