Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab107787 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Purity70 - 90% by HPLC.

  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • 3 hydroxy 3 methylglutaryl CoA reductase
    • 3 hydroxy 3 methylglutaryl Coenzyme A reductase
    • 3 hydroxymethylglutaryl CoA reductase
    • 3-hydroxy-3-methylglutaryl CoA reductase (NADPH)
    • 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    • 3H3M
    • HMDH_HUMAN
    • HMG CoA reductase
    • HMG CoAR
    • HMG-CoA reductase
    • Hmgcr
    • Hydroxymethylglutaryl CoA reductase
    • LDLCQ3
    • MGC103269
    • Red
    see all
  • FunctionThis transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis.
  • PathwayMetabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.
  • Sequence similaritiesBelongs to the HMG-CoA reductase family.
  • Cellular localizationEndoplasmic reticulum membrane. Peroxisome membrane.
  • Information by UniProt

References for Human HMGCR peptide (ab107787)

ab107787 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"