The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-HSD3a antibody (ab50415)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
3 alpha HSD1
3-alpha-hydroxysteroid dehydrogenase type I
Aldo keto reductase family 1 member C4
Aldo-keto reductase family 1 member C4
Dihydrodiol dehydrogenase 4
FunctionCatalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
Tissue specificityLiver specific.
Sequence similaritiesBelongs to the aldo/keto reductase family.
Post-translational modificationsThe N-terminus is blocked.