Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • Accession5654
    • SpeciesHuman
    • Amino acids116 to 147

Associated products

Specifications

Our Abpromise guarantee covers the use of ab112516 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-htrA1 antibody (ab38611)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    Constituent: 100% dH2O

General Info

  • Alternative names
    • ARMD7
    • CARASIL
    • High-temperature requirement A serine peptidase 1
    • HtrA
    • HtrA serine peptidase 1
    • HTRA1
    • HTRA1_HUMAN
    • IGFBP5 protease
    • L56
    • ORF480
    • protease serine 11
    • Protease serine 11 (IGF binding)
    • PRSS11
    • Serine protease 11
    • Serine protease HTRA1
    • Serine protease HTRA1 precursor
    see all
  • FunctionProtease that regulate the availability of nsulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Represses signaling by TGF-beta family members.
  • Tissue specificityExpressed in a variety of tissues, with strongest expression in placenta.
  • Involvement in diseaseVariations in the promoter region of HTRA1 are the cause of susceptibility to age-related macular degeneration type 7 (ARMD7) [MIM:610149]. ARMD is the leading cause of vision loss and blindness among older individuals in the developed word. It is classified as either dry (nonneovascular) or wet (neovascular). ARMD7 is a wet form, in which new blood vessels form and break beneath the retina. This leakage causes permanent damage to surrounding retinal tissue, distorting and destroying central vision. Wet ARMD is more prevalent among Asians than Caucasians.
    Defects in HTRA1 are the cause of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) [MIM:600142]. CARASIL is characterized by nonhypertensive cerebral small-vessel arteriopathy with subcortical infarcts, alopecia, and spondylosis, with an onset in early adulthood. On neuropathological examination, arteriosclerosis associated with intimal thickening and dense collagen fibers, loss of vascular smooth-muscle cells, and hyaline degeneration of the tunica media has been observed in cerebral small arteries.
  • Sequence similaritiesBelongs to the peptidase S1B family.
    Contains 1 IGFBP N-terminal domain.
    Contains 1 Kazal-like domain.
    Contains 1 PDZ (DHR) domain.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Human htrA1 peptide (ab112516)

ab112516 has not yet been referenced specifically in any publications.

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