Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-TGPPAKKAISELP
    • Amino acids
      135 to 147

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23067 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Iba1 antibody (ab5076)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • AIF 1
    • AIF-1
    • Aif1
    • AIF1 protein
    • AIF1_HUMAN
    • Allograft inflammatory factor 1
    • Allograft inflammatory factor 1 splice variant G
    • allograft inflammatory factor-1 splice variant Hara-1
    • balloon angioplasty responsive transcription
    • BART 1
    • G1
    • G1 putative splice variant of allograft inflamatory factor 1
    • IBA 1
    • IBA1
    • interferon gamma responsive transcript
    • Interferon responsive transcript 1
    • interferon responsive transcript factor 1
    • Ionized calcium binding adapter molecule 1
    • ionized calcium-binding adapter molecule
    • Ionized calcium-binding adapter molecule 1
    • IRT 1
    • IRT1
    • Microglia response factor
    • MRF1
    • Protein g1
    see all
  • Function
    Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
  • Tissue specificity
    Detected in T-lymphocytes and peripheral blood mononuclear cells.
  • Sequence similarities
    Contains 2 EF-hand domains.
  • Post-translational
    modifications
    Phosphorylated on serine residues.
  • Cellular localization
    Cytoplasm > cytoskeleton. Cell projection > ruffle membrane. Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.
  • Information by UniProt

References

ab23067 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Thank you for contacting us.

Unfortunately, we do not have a negative control image for ICC at hand.

However, we do have the peptide available, which can be used as as blocking peptide in this case to check if the astrocytes staining ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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