Overview

  • Product nameAnti-Human IgM antibody [MA2]
    See all Human IgM primary antibodies
  • Description
    Mouse monoclonal [MA2] to Human IgM
  • SpecificityMu-chain of human IgM, Fab - region localized epitope.
  • Tested applicationsSuitable for: ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    IgM from human serum.

  • General notesConcentration varies from lot to lot and can be provided on request.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.1% Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • PurityProtein A purified
  • Purification notesPurity tested by electrophoresis.
  • ClonalityMonoclonal
  • Clone numberMA2
  • MyelomaSp2/0
  • IsotypeIgG2b
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab1948 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.

Target

  • RelevanceIgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences. IgM measurement yields information about the body's immediate resistance and response to infection as well as information related to specific diseases. Decreased levels are associated with immune deficiency states, hereditary deficiencies, and myeloma. Increased levels can be associated with Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease.
  • Cellular localizationCell Membrane and Secreted
  • Database links
  • Alternative names
    • Immunoglobin heavy chain constant region mu edit item name - Immunoglobin heavy chain mu constant region antibody
    • Immunoglobin heavy chain constant region mu antibody
    • AGM1 antibody
    • Constant region of heavy chain of IgM antibody
    • DKFZp686I15196 antibody
    • DKFZp686I15212 antibody
    • FLJ00385 antibody
    • Ig mu chain C region antibody
    • IGHM antibody
    • IgM heavy chain constant region antibody
    • Immunoglobin heavy constant mu antibody
    • Immunoglobulin mu antibody
    • MGC104996 antibody
    • MGC52291 antibody
    • MU antibody
    • VH antibody
    see all

References for Anti-Human IgM antibody [MA2] (ab1948)

ab1948 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"