Overview

  • Product nameAnti-Human IgM antibody [MH15-1]
    See all Human IgM primary antibodies
  • Description
    Mouse monoclonal [MH15-1] to Human IgM
  • SpecificityThe monoclonal is highly specific for the IgM isotype.
  • Tested applicationsSuitable for: IHC-P, IHC-Fr, ICCmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Isolated IgM (Human).

  • Positive control
    • Tonsil.

Properties

Applications

Our Abpromise guarantee covers the use of ab34029 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
IHC-Fr
ICC
  • Application notesICC: 1/5 - 1/10.
    IHC-Fr: 1/5 - 1/10.
    IHC-P: 1/5 - 1/10 (based on the Indirect Method). With a normal ABC Method the dilution can be 5-10 times higher, but the optimal dilution should be tested by serial dilution. Perform protease digestion trypsin pretreatment. Dilute immediately before use with PBS or TRIS.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceIgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences. IgM measurement yields information about the body's immediate resistance and response to infection as well as information related to specific diseases. Decreased levels are associated with immune deficiency states, hereditary deficiencies, and myeloma. Increased levels can be associated with Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease.
    • Cellular localizationCell Membrane and Secreted
    • Database links
    • Alternative names
      • Immunoglobin heavy chain constant region mu edit item name - Immunoglobin heavy chain mu constant region antibody
      • Immunoglobin heavy chain constant region mu antibody
      • AGM1 antibody
      • Constant region of heavy chain of IgM antibody
      • DKFZp686I15196 antibody
      • DKFZp686I15212 antibody
      • FLJ00385 antibody
      • Ig mu chain C region antibody
      • IGHM antibody
      • IgM heavy chain constant region antibody
      • Immunoglobin heavy constant mu antibody
      • Immunoglobulin mu antibody
      • MGC104996 antibody
      • MGC52291 antibody
      • MU antibody
      • VH antibody
      see all

    References for Anti-Human IgM antibody [MH15-1] (ab34029)

    ab34029 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"