Overview

Description

  • NatureRecombinant
  • SourceE. coli
  • Amino Acid Sequence
    • AccessionP29218
    • SpeciesHuman
    • SequenceMGSSHHHHHHSSGLVPRGSHMADPWQECMDYAVTLARQAGEVVCEAIKNE MNVMLKSSPVDLVTATDQKVEKMLISSIKEKYPSHSFIGEESVAAGEKSI LTDNPTWIIDPIDGTTNFVHRFPFVAVSIGFAVNKKIEFGVVYSCVEGKM YTARKGKGAFCNGQKLQVSQQEDITKSLLVTELGSSRTPETVRMVLSNME KLFCIPVHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDVAGAGIIVTE AGGVLMDVTGGPFDLMSRRVIAANNRILAERIAKEIQVIPLQRDDED
    • Molecular weight32 kDa including tags
    • Amino acids1 to 277
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab99519 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry
    MALDI-TOF
  • Purity> 95 % by SDS-PAGE.
    ab99519 was purified using conventional chromatography.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, pH 8.0

General info

  • Alternative names
    • IMP
    • IMP 1
    • IMPA
    • IMPA 1
    • IMPA1
    • IMPA1_HUMAN
    • IMPase
    • IMPase 1
    • Inositol 1(or 4) monophosphatase
    • Inositol monophosphatase
    • Inositol monophosphatase 1
    • Inositol(myo) 1(or 4) monophosphatase 1
    • Inositol-1(or 4)-monophosphatase 1
    • Lithium sensitive myo inositol monophosphatase A1
    • Lithium-sensitive myo-inositol monophosphatase A1
    see all
  • FunctionResponsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.
  • PathwayPolyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.
  • Sequence similaritiesBelongs to the inositol monophosphatase family.
  • Cellular localizationCytoplasm.
  • Target information above from: UniProt accession P29218 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Human IMPA1 full length protein images

  • 15% SDS-PAGE analysis of 3µg ab99519.

References for Human IMPA1 full length protein (ab99519)

ab99519 has not yet been referenced specifically in any publications.

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