Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-SAFNFGTVPSNN
    • Amino acids1026 to 1037

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23081 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Importin 8 antibody (ab5263)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • FLJ26580
    • Imp 8
    • Imp8
    • Importin-8
    • Importin8
    • IPO 8
    • IPO8
    • IPO8_HUMAN
    • Ran binding protein 8
    • RAN BP8
    • Ran-binding protein 8
    • RANBP 8
    • RanBP8
    see all
  • FunctionSeems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19.
  • Sequence similaritiesBelongs to the importin beta family.
    Contains 1 importin N-terminal domain.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt

References for Human Importin 8 peptide (ab23081)

ab23081 has not yet been referenced specifically in any publications.

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