Endoplasmic reticulum (ER) to nucleus signalling 1
Endoplasmic reticulum to nucleus signaling 1
Endoplasmic reticulum-to-nucleus signaling 1
ER to nucleus signaling 1
Inositol requiring 1
Inositol requiring 1, S. cerevisiae, homolog of
Inositol requiring enzyme 1, S. cerevisiae, homolog of
Inositol requiring protein 1
inositol-requiring enzyme 1
Inositol-requiring protein 1
Serine/threonine protein kinase/endoribonuclease IRE1
FunctionSenses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
Tissue specificityUbiquitously expressed. High levels observed in pancreatic tissue.
Sequence similaritiesBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 KEN domain. Contains 1 protein kinase domain.