Overview

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab105483 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Purity70 - 90% by HPLC.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General info

  • Alternative names
    • IFI1
    • Iigp3
    • Iipg3
    • Immunity related GTPase family M protein 1
    • Immunity related GTPase family, M
    • Immunity-related GTPase family M protein
    • Immunity-related GTPase family M protein 1
    • Interferon inducible protein 1
    • Interferon-inducible protein 1
    • Irgm
    • IRGM_HUMAN
    • IRGM1
    • LPS-stimulated RAW 264.7 macrophage protein 47 homolog
    • LRG 47
    • LRG-47
    • LRG-47-like protein
    • LRG47
    • MGC149263
    • MGC149264
    see all
  • FunctionPutative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility.
  • Tissue specificityWidely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes.
  • Involvement in diseaseDefects in IRGM are the cause of susceptibility to inflammatory bowel disease type 19 (IBD19) [MIM:612278]. A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
  • Sequence similaritiesBelongs to the interferon-inducible GTPase family.
  • Cellular localizationGolgi apparatus membrane. Cell membrane. Cytoplasmic vesicle > phagosome membrane. Cytoplasmic vesicle > autophagosome membrane. Cell projection > phagocytic cup. Behaves like an integral membrane protein (By similarity). Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes (By similarity). Preferentially associated with cis- and medial-Golgi.
  • Information by UniProt

References for Human IRGM peptide (ab105483)

ab105483 has not yet been referenced specifically in any publications.

Product Wall

Voici le protocole utilisé par le laboratoire : - 10µg de lysat par puit (under reducing conditions), - transfert sur membrane nitrocellulose (1 heure, 90V), - blocage avec 5% de BSA (1 heure, température ambiante), - incubation du primaire...

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Je suis désolé d'apprendre que ab93901 ne vous donne pas de bons résultats pour la détection de IRGM endogène. Le laboratoire et moi-même aimerions avoir plus d'informations sur le protocole que vous avez utilisé avec cet anticorps. Veuillez tr...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"