Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • AccessionQ8NHM5
    • SpeciesHuman
    • SequenceC-FGQVEEKLLQKLS
    • Amino acids1324 to 1336

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23079 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-KDM2B antibody (ab5199)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • [Histone-H3]-lysine-36 demethylase 1B
    • CXXC-type zinc finger protein 2
    • CXXC2
    • F box and leucine rich repeat protein 10
    • F box protein FBL10
    • F-box and leucine-rich repeat protein 10
    • F-box protein FBL10
    • F-box/LRR-repeat protein 10
    • Fbl10
    • FBXL10
    • JEMMA (Jumonji domain EMSY interactor methyltransferase motif) protein
    • JHDM1B
    • JmjC domain-containing histone demethylation protein 1B
    • Jumonji C domain containing histone demethylase 1B
    • Jumonji domain-containing EMSY-interactor methyltransferase motif protein
    • kdm2b
    • KDM2B_HUMAN
    • Lysine (K) specific demethylase 2B
    • Lysine-specific demethylase 2B
    • PCCX2
    • Protein containing CXXC domain 2
    • Protein JEMMA
    • Protein-containing CXXC domain 2
    see all
  • FunctionHistone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
  • Sequence similaritiesBelongs to the JHDM1 histone demethylase family.
    Contains 1 CXXC-type zinc finger.
    Contains 1 F-box domain.
    Contains 1 JmjC domain.
    Contains 7 LRR (leucine-rich) repeats.
    Contains 1 PHD-type zinc finger.
  • DomainThe JmjC domain mediates demethylation activity (By similarity). It is also required for repression of ribosomal RNA genes.
  • Cellular localizationNucleus > nucleolus.
  • Information by UniProt

References for Human KDM2B peptide (ab23079)

ab23079 has not yet been referenced specifically in any publications.

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