Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
GASC 1 protein
Gene amplified in squamous cell carcinoma 1 protein
JmjC domain containing histone demethylation protein 3C
JmjC domain-containing histone demethylation protein 3C
Jumonji domain containing 2C
Jumonji domain containing protein 2C
Jumonji domain-containing protein 2C
Lysine (K) specific demethylase 4C
Lysine-specific demethylase 4C
Tudor domain containing 14C
FunctionHistone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Tissue specificityOverexpressed in several esophageal squamous cell carcinomas (ESCs).