Human KDM6A / UTX peptide (ab36937)

Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • AccessionO15550
    • SpeciesHuman

Associated products

Specifications

Our Abpromise guarantee covers the use of ab36937 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • FormLiquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • bA386N14.2
    • bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX)
    • bA386N14.2 ubiquitously transcribed X chromosome tetratricopeptide repeat protein UTX
    • DKFZp686A03225
    • Histone demethylase UTX
    • KABUK2
    • Kdm6a
    • KDM6A_HUMAN
    • Lysine (K) specific demethylase 6A
    • Lysine K specific demethylase 6A
    • Lysine specific demethylase 6A ubiquitously transcribed tetratricopeptide repeat gene X chromosome
    • Lysine-specific demethylase 6A
    • MGC141941
    • Ubiquitously transcribed tetratricopeptide repeat X chromosome
    • Ubiquitously transcribed tetratricopeptide repeat protein X linked
    • Ubiquitously transcribed TPR gene on the X chromosome
    • Ubiquitously transcribed TPR protein on the X chromosome
    • Ubiquitously transcribed X chromosome tetratricopeptide repeat protein
    • Ubiquitously-transcribed TPR protein on the X chromosome
    • Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein
    • UTX
    see all
  • FunctionHistone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitent with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.
  • Sequence similaritiesBelongs to the UTX family.
    Contains 1 JmjC domain.
    Contains 8 TPR repeats.
  • Cellular localizationNucleus.
  • Information by UniProt

References for Human KDM6A / UTX peptide (ab36937)

ab36937 has not yet been referenced specifically in any publications.

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Thank you for your inquiry.

I apologize for the confusion. The peptides you purchased are in fact short sequences within the ranges listed on the datasheet. The "protein length" section just comes from SwissProt and is a reference f...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"