The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Conventional kinesin heavy chain
kinesin 1 (110-120kD)
Kinesin 1 heavy chain
Kinesin family member 5B
Kinesin heavy chain
kinesin, heavy chain, ubiquitous
Kinesin-1 heavy chain
Ubiquitous kinesin heavy chain
FunctionMicrotubule-dependent motor required for normal distribution of mitochondria and lysosomes.
Sequence similaritiesBelongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily. Contains 1 kinesin motor domain.
DomainComposed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.
Cellular localizationCytoplasm, cytoskeleton. Uniformly distributed between soma and neurites in hippocampal neurons.