Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      C-QPVAVRGGGGKQV
    • Amino acids
      951 to 963

Specifications

Our Abpromise guarantee covers the use of ab23262 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Conventional kinesin heavy chain
    • KIF 5B
    • KIF5B
    • Kinesin 1
    • kinesin 1 (110-120kD)
    • Kinesin 1 heavy chain
    • Kinesin family member 5B
    • Kinesin heavy chain
    • kinesin, heavy chain, ubiquitous
    • Kinesin-1 heavy chain
    • Kinesin1
    • KINH
    • KINH_HUMAN
    • KNS
    • KNS 1
    • KNS1
    • Ubiquitous kinesin heavy chain
    • UKHC
    see all
  • Function
    Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes.
  • Sequence similarities
    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.
    Contains 1 kinesin motor domain.
  • Domain
    Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.
  • Cellular localization
    Cytoplasm, cytoskeleton. Uniformly distributed between soma and neurites in hippocampal neurons.
  • Information by UniProt

References

ab23262 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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