Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Accession
    • Species
      Human

Associated products

Specifications

Our Abpromise guarantee covers the use of ab25744 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-LAMP1 antibody - Lysosome Marker (ab24170)

  • Form
    Liquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • CD107 antigen like family member A
    • CD107 antigen-like family member A
    • CD107a
    • CD107a antigen
    • LAMP 1
    • LAMP-1
    • LAMP1
    • LAMP1_HUMAN
    • LAMPA
    • LGP120
    • lgpA
    • Lysosomal membrane glycoprotein 120KD
    • Lysosomal Associated Membrane Protein 1
    • Lysosome associated membrane glycoprotein 1
    • Lysosome-associated membrane glycoprotein 1
    • Lysosome-associated membrane protein 1
    • OTTHUMP00000040663
    see all
  • Function
    Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.
  • Sequence similarities
    Belongs to the LAMP family.
  • Post-translational
    modifications
    O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans.
  • Cellular localization
    Cell membrane. Endosome membrane. Lysosome membrane. This protein shuttles between lysosomes, endosomes, and the plasma membrane.
  • Information by UniProt

References

This product has been referenced in:
  • Shang S  et al. Intracellular TRPA1 mediates Ca2+ release from lysosomes in dorsal root ganglion neurons. J Cell Biol 215:369-381 (2016). Read more (PubMed: 27799370) »
  • Chu Y  et al. Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions. Neurobiol Dis 35:385-98 (2009). Read more (PubMed: 19505575) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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