Human LAT peptide (ab45595)

General Info

• Alternative names
  • 36 kDa phospho tyrosine adapter protein
  • 36 kDa phospho-tyrosine adapter protein
  • 36 kDa phospho-tyrosine adaptor protein

  • lat
  • LAT 1
  • LAT_HUMAN
  • LAT1
  • Linker for activation of T cells
  • Linker for activation of T cells family member 1
  • linker for activation of T cells, transmembrane adaptor
  • Linker for activation of T-cells family member 1
  • p36 38
  • p36-38
  • pp36

  see all
• Function
  Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
• Tissue specificity
  Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).
• Post-translational
  modifications
  Phosphorylated on tyrosines by ZAP-70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ.
  Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.
• Cellular localization
  Cell membrane. Present in lipid rafts.

• Target information above from: UniProt accession O43561 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt