Overview

Description

  • NatureSynthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab25890 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • FormLiquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • FLJ14594
    • LERN 1
    • LERN1
    • Leucine rich repeat and Ig domain containing 1
    • Leucine rich repeat neuronal 6A
    • Leucine rich repeat neuronal protein 1
    • Leucine rich repeat neuronal protein 6A
    • Leucine-rich repeat and immunoglobilin domain-containing protein 1
    • Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
    • Leucine-rich repeat neuronal protein 1
    • Leucine-rich repeat neuronal protein 6A
    • LIGO1_HUMAN
    • Lingo 1
    • LINGO1
    • LRR and Ig domain containing Nogo Receptor interating protein
    • Lrrn 6a
    • Lrrn6a
    • Lrrn6a protein
    • MGC17422
    • Nogo Receptor interacting protein
    • PRO227
    • UNQ201
    see all
  • FunctionFunctional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.
  • Tissue specificityExpressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients.
  • Sequence similaritiesContains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 11 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 LRRNT domain.
  • Post-translational
    modifications
    N-glycosylated. Contains predominantly high-mannose glycans.
  • Cellular localizationCell membrane.
  • Information by UniProt

References for Human Lingo1 peptide (ab25890)

ab25890 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. The peptide used to make the antibody is toward the end of the C-terminus, therefore the antibody will recognize the intracellular domain of the protein. I hope this information helps, please do not hesitate to contact...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"