Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab25890 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Form
    Liquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • FLJ14594
    • LERN 1
    • LERN1
    • Leucine rich repeat and Ig domain containing 1
    • Leucine rich repeat neuronal 6A
    • Leucine rich repeat neuronal protein 1
    • Leucine rich repeat neuronal protein 6A
    • Leucine-rich repeat and immunoglobilin domain-containing protein 1
    • Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
    • Leucine-rich repeat neuronal protein 1
    • Leucine-rich repeat neuronal protein 6A
    • LIGO1_HUMAN
    • Lingo 1
    • LINGO1
    • LRR and Ig domain containing Nogo Receptor interating protein
    • Lrrn 6a
    • Lrrn6a
    • Lrrn6a protein
    • MGC17422
    • Nogo Receptor interacting protein
    • PRO227
    • UNQ201
    see all
  • Function
    Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.
  • Tissue specificity
    Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients.
  • Sequence similarities
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 11 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 LRRNT domain.
  • Post-translational
    modifications
    N-glycosylated. Contains predominantly high-mannose glycans.
  • Cellular localization
    Cell membrane.
  • Information by UniProt

References

ab25890 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Thank you for your enquiry. The peptide used to make the antibody is toward the end of the C-terminus, therefore the antibody will recognize the intracellular domain of the protein. I hope this information helps, please do not hesitate to contact...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up