Human Luteinizing Hormone ELISA Kit (ab108651)

Overview

  • Product nameHuman Luteinizing Hormone ELISA Kit
    See all Luteinizing Hormone kits
  • Detection methodColorimetric
  • Sample type
    Serum
  • Assay typeSandwich (quantitative)
  • Sensitivity
    = 1 mIU/ml
  • Range
    1 mIU/ml - 200 mIU/ml
  • Assay durationMultiple steps standard assay
  • Species reactivity
    Reacts with: Human
  • Product overview

    ab108651 Luteinizing Hormone Human ELISA Kit is intended for the quantitative determination of luteinizing hormone (LH) concentration in human serum.

    Luteinizing hormone (LH) is produced in both men and women from the anterior pituitary gland in response to luteinizing hormone-releasing hormone (LH-RH or Gn-RH), which is released by the hypothalamus. LH, also called interstitial cell-stimulating hormone (ICSH) in men, is a glycoprotein with a molecular weight of approximately 30,000 daltons. It is composed of two noncovalently associated dissimilar amino acid chains, alpha and beta. The alpha chain is similar to that found in human thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH), and human chorionic gonadotropin (hCG). The differences between these hormones lie in the amino acid composition of their beta subunits, which account for their immunological differentiation.

    The basal secretion of LH in men is episodic and has the primary function of stimulating the interstitial cells (Leydig cells) to produce testosterone. The variation in LH concentrations in women is subject to the complex ovulatory cycle of healthy menstruating women, and depends on a sequence of hormonal events along the gonado-hypothalamic-pituitary axis.

  • Tested applicationsSuitable for: Sandwich ELISAmore details
  • PlatformMicroplate

Properties

  • FunctionPromotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
  • Tissue specificityPituitary gland.
  • Involvement in diseaseDefects in LHB are a cause of hypogonadism LHB-related (HGON-LHB) [MIM:152780]. Hypogonadism is characterized by infertility and pseudohermaphroditism.
  • Sequence similaritiesBelongs to the glycoprotein hormones subunit beta family.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Alternative names
    • LH-B
    • LHB
    • LSH-B
    • LSH-beta
    • LSHB_HUMAN
    • Luteinizing hormone subunit beta
    • Lutropin beta chain
    • Lutropin subunit beta
    see all
  • Database links

Applications

Our Abpromise guarantee covers the use of ab108651 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Sandwich ELISA Use at an assay dependent dilution.

Human Luteinizing Hormone ELISA Kit images

Protocols

References for Human Luteinizing Hormone ELISA Kit (ab108651)

ab108651 has not yet been referenced specifically in any publications.

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We do have no ELISA kit against LH, FSH or Progesterone which are tested against the rat proteins. We do have however such kits tested against the human protein, for which we have however not yet tested w...

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