Overview

  • Product nameHuman Mad2L2 peptide

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceTLTRQDLNFGQV (amino acids 1-14) of human Mad2L2.
    • Amino acids3 to 14

Specifications

Our Abpromise guarantee covers the use of ab11254 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThis product can be used as the blocking peptide for ab3630.
  • FormLiquid
  • Additional notesThis product can be used as the blocking peptide for ab3630.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: PBS

General Info

  • Alternative names
    • Homolog of REV7 S cerevisiae
    • hREV7
    • MAD2 (mitotic arrest deficient yeast, homolog) like 2
    • MAD2 homolog
    • MAD2 like 2
    • MAD2 mitotic arrest deficient like 2
    • MAD2-like protein 2
    • MAD2B
    • Mad2l2
    • MD2L2_HUMAN
    • Mitotic Arrest Deficient 2 L2
    • Mitotic arrest deficient 2-like protein 2
    • Mitotic arrest deficient homolog like 2
    • Mitotic arrest deficient like 2 (yeast)
    • Mitotic arrest deficient yeast homolog
    • Mitotic spindle assembly checkpoint protein MAD2B
    • Polymerase (DNA directed) zeta 2 accessory subunit
    • POLZ2
    • REV 7
    • REV7
    • REV7 homolog
    • Weakly similar to Mitotic MAD2 protein (S cerevisiae)
    see all
  • FunctionAdapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.
  • Tissue specificityUbiquitously expressed.
  • Sequence similaritiesContains 1 HORMA domain.
  • Cellular localizationNucleus. Cytoplasm > cytoskeleton > spindle. Cytoplasm.
  • Information by UniProt

References for Human Mad2L2 peptide (ab11254)

ab11254 has not yet been referenced specifically in any publications.

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