Mannose binding lectin protein C2 soluble opsonic defect
Mannose binding protein
Mannose binding protein C
Mannose binding protein C precursor
Mannose binding protein, serum
Mannose-binding protein C
Soluble mannose binding lectin
FunctionCalcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.
Tissue specificityPlasma protein produced mainly in the liver.
Involvement in diseaseNote=There is an association between low levels of MBL2 and a defect of opsonization which results in susceptibility to frequent and chronic infections.