Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab25851 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • CARD adapter inducing interferon beta
    • CARD adaptor inducing IFN beta
    • Cardif
    • DKFZp666M015
    • FLJ27482
    • FLJ41962
    • IFN B promoter stimulator 1
    • Interferon beta promoter stimulator protein 1
    • Ips 1
    • IPS-1
    • Ips1
    • KIAA1271
    • MAVS
    • MAVS_HUMAN
    • Mitochondrial anti viral signaling protein
    • Mitochondrial Antiviral Signaling
    • Mitochondrial antiviral signaling protein
    • Mitochondrial antiviral-signaling protein
    • Putative NF kappa B activating protein 031N
    • Putative NF-kappa-B-activating protein 031N
    • Virus induced signaling adapter
    • virus induced signaling adaptor
    • Virus-induced-signaling adapter
    • VISA
    see all
  • Function
    Required for innate immune defense against viruses. Acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.
  • Tissue specificity
    Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.
  • Sequence similarities
    Contains 1 CARD domain.
  • Domain
    Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with DDX58 and IFIH1.
  • Post-translational
    modifications
    Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination catalyzed by ITCH; ITCH-dependent polyubiquitination is mediated by the interaction with PCBP2 and leads to MAVS proteasomal degradation.
  • Cellular localization
    Mitochondrion outer membrane.
  • Information by UniProt

References

ab25851 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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