Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human

Specifications

Our Abpromise guarantee covers the use of ab39809 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • Bcl 2 related protein EAT/mcl1
    • Bcl-2-like protein 3
    • Bcl-2-related protein EAT/mcl1
    • BCL2 related
    • Bcl2-L-3
    • BCL2L3
    • EAT
    • Induced myeloid leukemia cell differentiation protein Mcl 1
    • Induced myeloid leukemia cell differentiation protein Mcl-1
    • MCL 1
    • MCL1
    • MCL1-ES
    • mcl1/EAT
    • MCL1_HUMAN
    • MCL1L
    • MCL1S
    • MGC104264
    • MGC1839
    • Myeloid Cell Leukemia 1
    • Myeloid cell leukemia ES
    • Myeloid cell leukemia sequence 1
    • Myeloid cell leukemia sequence 1 BCL2 related
    • Myeloid cell leukemia sequence 1 isoform 1
    • OTTHUMP00000032794
    • OTTHUMP00000032795
    • TM
    see all
  • Function
    Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
  • Sequence similarities
    Belongs to the Bcl-2 family.
  • Post-translational
    modifications
    Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.
    Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region.
    Phosphorylated on Thr-163. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.
  • Cellular localization
    Membrane. Cytoplasm. Mitochondrion. Nucleus > nucleoplasm. Cytoplasmic, associated with mitochondria.
  • Information by UniProt

References

ab39809 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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