Human MCM3 protein fragment (ab91701)
- Product nameHuman MCM3 protein fragment
- SourceE. coli
- Amino Acid Sequence
- SequenceNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVIL DDDLVDKAKP GDRVQVVGTYRCLPGKKGGYTSGTFRTV LIACNVKQMSKDAQPSFSAEDI AKIKKFSKTRSKDIFD QLAKSLAPSIHGHDYVKKAILCLLLGGVERDLEN GSHI RGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSG VGLTAA VTTDQETGERRLEAGAMVLADRGVVCIDEFDK MSDMDRTAIHEVMEQGRV TIAKAGIHARLNARCSVLAA ANPVYGRYDQYKTPMENIGLQDSLLSRFDL LFIMLDQM DPEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILAT DD PNFSQEDQQDTQIYEKHDNLLHGTKKKKEKMVSAAF MKKYIHVAKIIKPV LTQESATYIAEEYSRLRSQDSMSS DTARTSPVTARTLETLIRLATAHAKA RMSKTVDLQDAE EAVELVQYAYFKKVLEKEKKRKKRSEDESETEDEEEKS QEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMPQVH TPKTADSQET KESQKVELSESRLKAFKVALLDVFREAH AQSIGMNRLTESINRDSEEPFS SVEIQAALSKMQDDNQ VMVSEGIIFLI
- Amino acids182 to 808
Our Abpromise guarantee covers the use of ab91701 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Additional NotesProtein Identity confirmed by Mass Spectrometry (MS/MS) (acquired on initial reference batch)
- Concentration information loading...
Preparation and Storage
- Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
- ReconstitutionReconstitute with 84 µl aqua dest
- Cervical cancer proto oncogene 5
- DNA polymerase alpha holoenzyme associated P1
- DNA polymerase alpha holoenzyme associated protein P1
- DNA polymerase alpha holoenzyme-associated protein P1
- DNA replication factor MCM3
- DNA replication licensing factor MCM3
- HCC 5
- hRlf beta subunit
- Human cervical cancer proto oncogene 5
- MCM 3
- MCM3 minichromosome maintenance deficient 3
- Minichromosome maintenance complex component 3
- Minichromosome maintenance deficient 3
- Minichromosome maintenance protein 3
- P1 h
- P1 MCM3
- P1 Protein
- P102 protein
- Replication licensing factor beta subunit
- RLF beta subunit
- RLF subunit beta
- FunctionActs as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.
- Sequence similaritiesBelongs to the MCM family.
Contains 1 MCM domain.
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
- Cellular localizationNucleus.
Human MCM3 protein fragment images
The image shows an electrophoretic assay performed using an Agilent 5100 ALP. In some images coloured control bands can be seen at 15 kDa (green) and/or 240 kDa (purple). The protein-specific band is blue.
References for Human MCM3 protein fragment (ab91701)
ab91701 has not yet been referenced specifically in any publications.