Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-KMTVNGAPVPPLT
    • Amino acids332 to 344

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23085 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Mel18 antibody - ChIP Grade (ab5267)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • DNA binding protein Mel 18
    • DNA-binding protein Mel-18
    • Mel 18
    • MGC10545
    • PCGF 2
    • PCGF2
    • PCGF2_HUMAN
    • Polycomb group ring finger 2
    • Polycomb group RING finger protein 2
    • RING finger protein 110
    • RNF110
    • Zinc finger protein 144
    • ZNF 144
    • ZNF144
    see all
  • FunctionTranscriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
  • Tissue specificityDetected in all tissues examined with high expression found in placenta lung and kidney and low expression, in liver, pancreas and skeletal muscle.
  • Sequence similaritiesContains 1 RING-type zinc finger.
  • Post-translational
    modifications
    Phosphorylated. Homodimer formation is regulated by phosphorylation state with unphosphorylated protein forming homodimers.
  • Cellular localizationNucleus.
  • Information by UniProt

References for Human Mel18 peptide (ab23085)

ab23085 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab23085.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"