Human MMP11 full length protein (ab39310)

Overview

Description

  • NatureNatural
  • SourceNative
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids0 to 0

Specifications

Our Abpromise guarantee covers the use of ab39310 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

    SDS-PAGE

  • Purity> 95 % by SDS-PAGE.
    This protein is free of contaminating MMPs or TIMPs.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 0.02% Brij 35, 5mM Calcium chloride, 100mM Sodium chloride, 10mM Tris HCl, pH 7.4

General info

  • Alternative names
    • Matrix Metalloproteinase 11
    • Matrix Metalloproteinase 11
    • Matrix metalloproteinase-11
    • MM11
    • MM11
    • MMP 11
    • MMP-11
    • Mmp11
    • MMP11_HUMAN
    • SL 3
    • SL-3
    • SL3
    • ST 3
    • ST3
    • ST3
    • STMY 3
    • STMY3
    • STMY3
    • Stromelysin 3
    • Stromelysin 3
    • Stromelysin 3 precursor
    • Stromelysin 3 precursor
    • Stromelysin III
    • Stromelysin-3
    • Stromelysin3
    • StromelysinIII
    see all
  • FunctionMay play an important role in the progression of epithelial malignancies.
  • Tissue specificitySpecifically expressed in stromal cells of breast carcinomas.
  • Sequence similaritiesBelongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications
    The precursor is cleaved by a furin endopeptidase.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.
  • Target information above from: UniProt accession P24347 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

References for Human MMP11 full length protein (ab39310)

ab39310 has not yet been referenced specifically in any publications.

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The product ab39310, full length Human MMP11 protein (purified from stimulated human fibroblasts) is supplied as a mixture of zymogen and processed (cleaved) forms. I am unaware of any procedure to activate the MMP1...

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