Overview

Description

  • NatureNatural
  • Amino Acid Sequence 1
    • SpeciesHuman
    • Amino acids0 to 0
    Amino Acid Sequence 2
    • SpeciesHuman
    • Amino acids0 to 0

Specifications

Our Abpromise guarantee covers the use of ab39307 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    The enzyme is supplied as a mixture of the zymogen and active enzyme, in:
    Preservative: 0.01% Sodium Azide
    Constituents: 50% Glycerol, 0.025% Brij 35, 5mM Calcium chloride, 250mM Sodium chloride, 10 mM MES, pH 5.0

General info

  • Alternative names
    • Matrilysin
    • Matrilysin uterine
    • Matrin
    • Matrix Metalloproteinase 7
    • Matrix metalloproteinase-7
    • MMP 7
    • MMP-7
    • MMP7
    • MMP7_HUMAN
    • MPSL1
    • PUMP 1
    • Pump 1 protease
    • Pump-1 protease
    • PUMP1
    • Uterine Matrilysin
    • Uterine metalloproteinase
    see all
  • FunctionDegrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
  • Sequence similaritiesBelongs to the peptidase M10A family.
  • DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.
  • Target information above from: UniProt accession P09237 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

References for Human MMP7 full length protein (ab39307)

ab39307 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"