Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceSSRKQGSQPRGQQS-C
    • Amino acids2 to 15

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23259 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Mortality Factor 4 like 2 antibody (ab15700)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • CG6363
    • Eaf3
    • Esa1p associated factor 3 homolog
    • FWP006
    • HsT17725
    • MEAF3
    • MO4L1_HUMAN
    • MORF related gene on chromosome 15
    • MORF-related gene 15 protein
    • Morf4l1
    • MORFRG15
    • Mortality factor 4 like 1
    • Mortality factor 4 like protein 1
    • Mortality factor 4-like protein 1
    • MRG15
    • Protein MSL3-1
    • S863-6
    • Transcription factor-like protein MRG15
    see all
  • FunctionComponent of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.
  • Sequence similaritiesBelongs to the MRG family.
  • Cellular localizationNucleus.
  • Information by UniProt

References for Human MRG15 peptide (ab23259)

ab23259 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"