Overview

  • Product nameHuman MSH3 peptide

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab74606 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Purity70 - 90% by HPLC.

  • FormLiquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • Divergent upstream protein
    • DNA mismatch repair protein
    • DNA mismatch repair protein Msh 3
    • DNA mismatch repair protein MSH3
    • DUC 1
    • DUC1
    • DUG
    • DUP
    • hMSH3
    • MGC163306
    • MGC163308
    • Mismatch repair protein 1
    • MRP 1
    • MRP1
    • MSH 3
    • MSH3
    • MSH3_HUMAN
    • MutS homolog 3
    • MutS homolog 3 (E. coli)
    see all
  • FunctionComponent of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
  • Involvement in diseaseDefects in MSH3 are a cause of susceptibility to endometrial cancer (ENDMC) [MIM:608089].
  • Sequence similaritiesBelongs to the DNA mismatch repair mutS family. MSH3 subfamily.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Information by UniProt

References for Human MSH3 peptide (ab74606)

ab74606 has not yet been referenced specifically in any publications.

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