Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-LKVKPTLIAVRP
    • Amino acids636 to 647

Specifications

Our Abpromise guarantee covers the use of ab23174 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • DKFZp686F2281
    • Mata1l1
    • Metastasis associated 1 family member 2
    • Metastasis associated 1 like 1
    • Metastasis associated gene 1 like 1
    • Metastasis associated gene family member 2
    • Metastasis associated protein 2
    • Metastasis associated protein MTA 2
    • Metastasis associated protein MTA2
    • Mmta2
    • MTA1 L1 protein
    • MTA1L1
    • p53 target protein in deacetylase complex
    • PID
    see all
  • RelevanceThe p53 tumor suppressor gene integrates numerous signals that control cell life and death. There are several proteins that are involved in the p53 pathway, including Chk2, p53R2, p53AIP1, Noxa, PIDD, and MTA2. The transcriptional activity of p53 is modulated by protein stability and acetylation. MTA2, also termed MTA1L1, was found to be a subunit of nucleosome remodeling and deacetylating (NuRD) complex. MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylation of p53 by MTA2 represses p53 dependent transcriptional activation and modulates p53 mediated cell growth arrest and apoptosis. MTA2 is ubiquitously expressed in human tissues.
  • Cellular localizationNuclear

References for Human MTA2 peptide (ab23174)

ab23174 has not yet been referenced specifically in any publications.

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