Overview

  • Product name
    Human Myosin 18B peptide

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-DDVASIMKKYLQK
    • Amino acids
      2555 to 2567

Specifications

Our Abpromise guarantee covers the use of ab45499 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • BK125H2.1
    • DKFZp434C2422
    • DKFZp779C1668
    • MY18B_HUMAN
    • MYO18B
    • myosin 18B
    • myosin XVIIIB
    • Myosin-XVIIIb
    see all
  • Function
    May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.
  • Tissue specificity
    Selectively expressed in cardiac and skeletal muscles. Weakly expressed in testis, pancreas, placenta, prostate, lung and thymus.
  • Sequence similarities
    Contains 1 IQ domain.
    Contains 1 myosin head-like domain.
  • Developmental stage
    Reaches an expression peak in the third day after induction and remains at similar level during successive myotubule maturation.
  • Cellular localization
    Cytoplasm. Nucleus. Cytoplasm > myofibril > sarcomere. Punctate pattern in undifferentiated myoblasts. Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location was found in some cardiomyocytes.
  • Information by UniProt

References

ab45499 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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