Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human

Specifications

Our Abpromise guarantee covers the use of ab42791 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Human WASP sequence has a similar peptide sequence surrounding serine 483 and 484.
  • Applications

    Blocking

    ELISA

  • Form
    Liquid
  • Additional notes


    Phosphorylation regulates the activity of both WASP and N WASP. Dual phosphorylation of WASP on serine 483 and 484 by casein kinases increases its affinity for the ARP2/3 complex. Thus, dual phosphorylation may be important for formation of actin-based structures in various cell types.

    Human WASP sequence has a similar peptide sequence surrounding serine 483 and 484.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.05% Sodium Azide
    Constituents: PBS

General Info

  • Alternative names
    • DKFZp779G0847
    • MGC48327
    • N-WASP
    • Neural Wiskott Aldrich syndrome protein
    • Neural Wiskott-Aldrich syndrome protein
    • NWASP
    • Wasl
    • WASL_HUMAN
    • WASPB
    • Wiskott Aldrich syndrome gene like
    • Wiskott Aldrich syndrome gene like protein
    • Wiskott Aldrich syndrome like
    • WiskottAldrich syndrome like
    see all
  • Function
    Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression.
  • Sequence similarities
    Contains 1 CRIB domain.
    Contains 1 WH1 domain.
    Contains 2 WH2 domains.
  • Cellular localization
    Cytoplasm > cytoskeleton. Nucleus. Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated.
  • Information by UniProt

References

ab42791 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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