The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityHuman WASP sequence has a two amino acid difference in the region surrounding Tyrosine 291.
Blocking - Blocking peptide for Anti-N WASP (phospho Y256) antibody (ab23395)
Phosphorylation at serine and tyrosine residues regulates the activity of both proteins. WASP is tyrosine phosphorylated at tyrosine 291 after antigen receptor activation in B-cells and collagen stimulation of platelets. Phosphorylation of the analogous site in N WASP (Tyr-256) stimulates its activity, reduces nuclear N WASP, and is required for neurite extension.
Human WASP sequence has a two amino acid difference in the region surrounding Tyrosine 291.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
FunctionRegulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression.