Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human

Associated products

Specifications

Our Abpromise guarantee covers the use of ab39800 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-NALP2 antibody (ab36850)

    Western blot

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

General Info

  • Alternative names
    • CLR19.9
    • FLJ20510
    • Leucine rich repeat and PYD containing protein 2
    • LRR and PYD domains-containing protein 2
    • NACHT
    • NACHT domain
    • NACHT leucine rich repeat and PYD containing 2
    • NACHT LRR and PYD domains containing protein 2
    • NALP2
    • NALP2_HUMAN
    • NBS1
    • NLR family pyrin domain containing 2
    • NLRP2
    • Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 2
    • Nucleotide-binding site protein 1
    • PAN1
    • PYPAF2
    • PYRIN containing APAF1 like protein2
    • PYRIN domain and NACHT domain-containing protein 1
    • PYRIN-containing APAF1-like protein 2
    see all
  • Function
    Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
  • Tissue specificity
    Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain.
  • Sequence similarities
    Belongs to the NLRP family.
    Contains 1 DAPIN domain.
    Contains 8 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • Domain
    The DAPIN domain is necessary and sufficient for suppression of NFKB1 activation induced by TNF and for inducing IL1B secretion in collaboration with caspase-1. It is involved in interaction with PYCARD.
    When isolated, the NACHT domain is involved in interaction with CARD8. This interaction is not detected for the full-length protein, maybe due to autoinhibition, this inhibition might by relieved by an inducible change in protein folding.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

References for Human NALP2 peptide (ab39800)

ab39800 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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