Human Natriuretic Peptide Receptor B peptide (ab42264)

Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceQNRLLIRAREDFGVE
    • Amino acids288 to 302

Associated products

Specifications

Our Abpromise guarantee covers the use of ab42264 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Natriuretic Peptide Receptor B antibody (ab14357)

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.1% Acetic acid

  • ReconstitutionResuspend in 0.1% acetic acid for required concentration.

General Info

  • Alternative names
    • AMDM
    • ANP-B
    • ANPB
    • ANPR-B
    • ANPRB
    • ANPRB_HUMAN
    • Atrial natriuretic peptide B type receptor
    • Atrial natriuretic peptide receptor 2
    • Atrial natriuretic peptide receptor type B
    • Atrionatriuretic peptide receptor B
    • GC-B
    • GCB
    • Guanylate cyclase B
    • GUC 2B
    • GUC2B
    • GUCY2B
    • Natriuretic peptide receptor B
    • Natriuretic peptide receptor B/guanylate cyclase B
    • NPR-B
    • Npr2
    • NPRB
    • NPRBi
    see all
  • FunctionReceptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.
  • Involvement in diseaseDefects in NPR2 are the cause of acromesomelic dysplasia Maroteaux type (AMDM) [MIM:602875]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDM is an autosomal recessive form characterized by axial skeletal involvement with wedging of vertebral bodies. In AMDM all skeletal elements are present but show abnormal rates of linear growth.
  • Sequence similaritiesBelongs to the adenylyl cyclase class-4/guanylyl cyclase family.
    Contains 1 guanylate cyclase domain.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Phosphorylation of the protein kinase-like domain is required for full activation by CNP.
  • Cellular localizationMembrane.
  • Information by UniProt

References for Human Natriuretic Peptide Receptor B peptide (ab42264)

ab42264 has not yet been referenced specifically in any publications.

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