Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      CSESTKRKLASAV
    • Amino acids
      378 to 390

Associated products

Specifications

Our Abpromise guarantee covers the use of ab22781 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-NCF1 antibody (ab795)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • 47 kDa autosomal chronic granulomatous disease protein
    • 47 kDa neutrophil oxidase factor
    • NADPH oxidase organizer 2
    • NCF 47K
    • NCF-1
    • NCF-47K
    • Ncf1
    • NCF1_HUMAN
    • Neutrophil cytosol factor 1
    • Neutrophil cytosolic factor 1
    • neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1)
    • Neutrophil NADPH oxidase factor 1
    • Nox organizer 2
    • Nox organizing protein 2
    • Nox-organizing protein 2
    • NOXO2
    • p47 phox
    • p47-phox
    • SH3 and PX domain containing protein 1A
    • SH3 and PX domain-containing protein 1A
    • SH3PXD1A
    see all
  • Function
    NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
  • Involvement in disease
    Defects in NCF1 are the cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 1 (CGD1) [MIM:233700]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.
  • Sequence similarities
    Contains 1 PX (phox homology) domain.
    Contains 2 SH3 domains.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

References

ab22781 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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