Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceGNSAGPKSMEVSC
    • Amino acids382 to 394

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45488 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-NDRG1 antibody (ab37897)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

General Info

  • Alternative names
    • 42 kDa
    • Anti GC4
    • cap43
    • cmt4d
    • Differentiation related gene1 protein
    • Differentiation-related gene 1 protein
    • Drg 1
    • DRG-1
    • drg1
    • gc4
    • GC4 antibody
    • hmsnl
    • Human mRNA for RTP complete cds
    • N myc downstream regulated gene 1
    • N myc downstream regulated gene 1 protein
    • N-myc downstream-regulated gene 1 protein
    • Ndr 1
    • ndr1
    • NDRG 1
    • Ndrg1
    • NDRG1 protein
    • NDRG1_HUMAN
    • Nickel specific induction protein
    • Nickel specific induction protein Cap43
    • Nickel-specific induction protein Cap43
    • nmsl
    • Nmyc downstream regulated
    • Nmyc downstream regulated gene1
    • Nmyc downstream regulated gene1 protein
    • Protein NDRG1
    • Protein regulated by oxygen 1
    • Protein regulated by oxygen1
    • Proxy1
    • Reduced in tumor
    • Reducin
    • Reducing agents and tunicamycin responsive protein
    • Reducing agents and tunicamycin-responsive protein
    • Rit42
    • RTP
    • targ1
    • TDD5
    • tdds
    • Tunicamycin responsive protein
    see all
  • FunctionMay have a growth inhibitory role.
  • Tissue specificityUbiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Reduced expression in adenocarcinomas compared to normal tissues. In colon, prostate and placental membranes, the cells that border the lumen show the highest expression.
  • Involvement in diseaseDefects in NDRG1 are the cause of Charcot-Marie-Tooth disease type 4D (CMT4D) [MIM:601455]; also known as hereditary motor and sensory neuropathy Lom type (HMSNL). CMT4D is a recessive form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy and primary peripheral axonal neuropathy. Demyelinating CMT neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention, autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4.
  • Sequence similaritiesBelongs to the NDRG family.
  • Cellular localizationCytoplasm. Nucleus. Cell membrane. Whereas in prostate epithelium and placental chorion it is located in both the cytoplasm and the nucleus, nuclear staining is not observed in colon epithelium cells. Instead its localization changes from the cytoplasm to the plasma membrane during differentiation of colon carcinoma cell lines in vitro.
  • Information by UniProt

References for Human NDRG1 peptide (ab45488)

ab45488 has not yet been referenced specifically in any publications.

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