Human NDUFAF4 full length protein (ab134610)

Overview

  • Product nameHuman NDUFAF4 full length protein
  • DescriptionHuman NDUFAF4 full length protein

Description

  • NatureRecombinant
  • SourceE. coli
  • Amino Acid Sequence
    • AccessionQ9P032
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MGSMGALVIR GIRNFNLENR AEREISKMKP SVAPRHPSTN SLLREQISLY PEVKGEIARK DEKLLSFLKD VYVDSKDPVS SLQVKAAETC QEPKEFRLPK DHHFDMINIK SIPKGKISIV EALTLLNNHK LFPETWTAEK IMQEYQLEQK DVNSLLKYFV TFEVEIFPPE DKKAIRSK
    • Molecular weight23 kDa including tags
    • Amino acids1 to 175
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab134610 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity> 85 % by SDS-PAGE.
    ab134610 was purified using conventional chromatography techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.88% Sodium chloride

General info

  • Alternative names
    • C6orf66
    • Hormone-regulated proliferation-associated protein of 20 kDa
    • HRPAP20
    • HSPC125
    • My013
    • NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4
    • NDUF4_HUMAN
    • Ndufaf4
    see all
  • FunctionInvolved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion.
  • Involvement in diseaseDefects in NDUFAF4 are a cause of mitochondrial complex I deficiency (MT-C1D) [MIM:252010]. A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease.
  • Sequence similaritiesBelongs to the NDUFAF4 family.
  • Post-translational
    modifications
    Phosphorylated on serine. Prolactin stimulate serine phosphorylation.
  • Cellular localizationMitochondrion.
  • Target information above from: UniProt accession Q9P032 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Human NDUFAF4 full length protein images

  • 15% SDS-PAGE analysis of ab134610 (3µg).

References for Human NDUFAF4 full length protein (ab134610)

ab134610 has not yet been referenced specifically in any publications.

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