Overview

  • Product name
    Human Neuro D4 peptide

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-HLKEKASAYITLT
    • Amino acids
      341 to 353

Associated products

Specifications

Our Abpromise guarantee covers the use of ab22971 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Neuro D4 antibody (ab3940)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • BAF45B
    • BRG1-associated factor 45B
    • D4
    • D4 zinc and double PHD fingers family 1
    • DPF1
    • DPF1_HUMAN
    • NEUD4
    • Neuro d4 homolog
    • Zinc and double PHD fingers family 1
    • Zinc finger protein neuro-d4
    see all
  • Function
    May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
  • Sequence similarities
    Belongs to the requiem/DPF family.
    Contains 2 PHD-type zinc fingers.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt

References

ab22971 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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