Overview

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab17100 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General info

  • Alternative names
    • atonal
    • basic helix loop helix transcription factor
    • BETA 2
    • Beta cell E box transactivator 2
    • BETA2
    • BETA2
    • BHF 1
    • BHF1
    • BHF1
    • bHLHa3
    • class A basic helix loop helix protein 3
    • Class A basic helix-loop-helix protein 3
    • MODY 6
    • MODY6
    • NDF1_HUMAN
    • NEUROD
    • NeuroD1
    • Neurogenic differentiation 1
    • Neurogenic differentiation factor 1
    • Neurogenic differentiation factor 1
    • neurogenic helix loop helix protein NEUROD
    • NIDDM
    • NIDDM
    see all
  • FunctionDifferentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. Transcriptional activator. Binds to the insulin gene E-box.
  • Involvement in diseaseDefects in NEUROD1 are the cause of maturity-onset diabetes of the young type 6 (MODY6) [MIM:606394]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
  • Sequence similaritiesContains 1 basic helix-loop-helix (bHLH) domain.
  • Post-translational
    modifications
    Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth.
  • Cellular localizationCytoplasm. Nucleus.
  • Target information above from: UniProt accession Q13562 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

References for Human NeuroD1 peptide (ab17100)

ab17100 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab17100.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"