Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.
ReconstitutionDissolve in a small volume of 30% ethanol in water (EtOH/H20 @ 3/7: V/V) or 25% acetonitrile in water (AcCN/H20 @ 25/75: V/V), and then dilute to desired concentration in appropriate buffer for specific use
FunctionAfter binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Involvement in diseaseDefects in CHRNA4 are the cause of nocturnal frontal lobe epilepsy type 1 (ENFL1) [MIM:600513]; also symbolized ADNFLE. ENFL1 is an autosomal dominant epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements.
Sequence similaritiesBelongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub-subfamily.