Human Nicotinic Acetylcholine Receptor alpha 4 peptide (ab99319)

Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human

Associated products

Specifications

Our Abpromise guarantee covers the use of ab99319 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Nicotinic Acetylcholine Receptor alpha 4 antibody (ab41172)

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

  • Reconstitution
    Dissolve in a small volume of 30% ethanol in water (EtOH/H20 @ 3/7: V/V) or 25% acetonitrile in water (AcCN/H20 @ 25/75: V/V), and then dilute to desired concentration in appropriate buffer for specific use

General Info

  • Alternative names
    • A4 nicotinic receptor
    • Acetylcholine receptor alpha 4 neural
    • Acetylcholine receptor neuronal nicotinic alpha 4 subunit
    • ACH 4
    • ACH4
    • ACHA4_HUMAN
    • AChR
    • Acra 4
    • Acra4
    • Alpha4 nAChR
    • BFNC
    • Cholinergic receptor nicotinic alpha 4
    • Cholinergic receptor nicotinic alpha polypeptide 4
    • CHRNA 4
    • CHRNA4
    • EBN
    • EBN 1
    • EBN1
    • NACHR
    • NACRA 4
    • NACRA4
    • Neuronal acetylcholine receptor subunit alpha-4
    • Neuronal nicotinic acetylcholine receptor alpha 4 subunit
    see all
  • Function
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • Involvement in disease
    Defects in CHRNA4 are the cause of nocturnal frontal lobe epilepsy type 1 (ENFL1) [MIM:600513]; also symbolized ADNFLE. ENFL1 is an autosomal dominant epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements.
  • Sequence similarities
    Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub-subfamily.
  • Cellular localization
    Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt

References

ab99319 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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