Human Nicotinic Acetylcholine Receptor alpha 7 peptide (ab24285)

Overview

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab24285 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • 7nAChR
    • a7 nicotinic acetylcholine receptor
    • acetylcholine receptor, neuronal nicotinic, alpha-7 subunit
    • ACHA7_HUMAN
    • AChR
    • Acra7
    • alpha 7 neuronal nicotinic acetylcholine receptor
    • alpha-7 nicotinic cholinergic receptor subunit
    • alpha7
    • cholinergic receptor, neuronal nicotinic, alpha polypeptide 7
    • cholinergic receptor, nicotinic, alpha 7
    • cholinergic receptor, nicotinic, alpha 7 (neuronal)
    • cholinergic receptor, nicotinic, alpha polypeptide 7
    • CHRNA7
    • CHRNA7-2
    • NACHRA7
    • neuronal acetylcholine receptor protein, alpha-7 chain
    • Neuronal acetylcholine receptor subunit alpha-7
    see all
  • FunctionAfter binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
  • Sequence similaritiesBelongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub-subfamily.
  • Cellular localizationCell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt

References for Human Nicotinic Acetylcholine Receptor alpha 7 peptide (ab24285)

This product has been referenced in:
  • Mielke JG & Mealing GA Cellular distribution of the nicotinic acetylcholine receptor alpha7 subunit in rat hippocampus. Neurosci Res 65:296-306 (2009). WB . Read more (PubMed: 19682509) »

See 1 Publication for this product

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The buffer contituents are:

30 mM HEPES
150 mM NaCl
2 mM EDTA
0.001% Tween 20
At pH 6.75

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"