Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-EAWPGKKPTPSLLI
    • Amino acids114 to 127

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23096 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-NIPP1 antibody (ab5300)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Activator of RNA decay
    • ARD 1
    • ARD-1
    • ARD1
    • Homolog of E.coli RNase E
    • NIPP 1
    • NIPP-1
    • NIPP1
    • Nuclear inhibitor of protein phosphatase 1
    • nuclear inhibitor of protein phosphatase-1 alpha
    • Nuclear subunit of PP1
    • PP1R8_HUMAN
    • PPP1R8
    • PRO2047
    • Protein phosphatase 1 regulatory inhibitor subunit 8
    • Protein phosphatase 1 regulatory subunit 8
    • RNase E
    • RNase E, E. coli, homolog of
    see all
  • FunctionInhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.
    Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.
  • Tissue specificityUbiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alpha (>90%) and isoform Beta were found in brain, heart and kidney. Isoform Gamma is mainly found in B-cells and T-lymphocytes, and has been found in 293 embryonic kidney cells.
  • Sequence similaritiesContains 1 FHA domain.
  • DomainHas a basic N- and C-terminal and an acidic central domain.
  • Post-translational
    modifications
    May be inactivated by phosphorylation on Ser-199 or Ser-204 (By similarity). Phosphorylated by Lyn in vitro on Tyr-264, and also on Tyr-335 in the presence of RNA.
  • Cellular localizationNucleus. Nucleus speckle. Primarily, but not exclusively, nuclear and Cytoplasm. Found mainly in the cytoplasm.
  • Information by UniProt

References for Human NIPP1 peptide (ab23096)

ab23096 has not yet been referenced specifically in any publications.

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