Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-SWARGPPKFESVP
    • Amino acids
      962 to 974

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45573 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-NIR1 antibody (ab21197)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • CORD5
    • Membrane associated phosphatidylinositol transfer protein 3
    • membrane-associated 3
    • Membrane-associated phosphatidylinositol transfer protein 3
    • MGC157740
    • MGC157741
    • NIR 1
    • NIR-1
    • NIR1
    • Phosphatidylinositol transfer protein
    • Phosphatidylinositol transfer protein, membrane-associated 3
    • PITM3_HUMAN
    • PITPNM
    • PITPnm 3
    • PITPNM family member 3
    • Pitpnm3
    • PYK2 N terminal domain interacting receptor 1
    • Pyk2 N-terminal domain-interacting receptor 1
    • RDGBA3
    • Retinal degeneration B alpha 3
    see all
  • Function
    Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions.
  • Tissue specificity
    Detected in brain and spleen, and at low levels in ovary.
  • Involvement in disease
    Defects in PITPNM3 are the cause of cone-rod dystrophy type 5 (CORD5) [MIM:600977]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.
  • Sequence similarities
    Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.
    Contains 1 DDHD domain.
  • Cellular localization
    Endomembrane system.
  • Information by UniProt

References

ab45573 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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